To function normally, nearly every cell in the human body relies on G-protein coupled receptors (GPCRs) to receive and send ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...

One of the most important mechanisms is receptor-mediated signaling. A peptide attaches to a specific receptor on the cell surface, which then activates intracellular proteins such as kinases or ...

The only route for S1P formation is via the phosphorylation of sphingosine at its C1 hydroxyl group by the sphingosine kinases. Two sphingosine kinases exist, SPHK1 and SPHK2. These are intracellular ...

Regeneration has fascinated humankind for millennia — think of Greek mythology figures such as the giant Tityus (whose liver could regenerate) or the serpent Hydra (that grew two heads for every one ...

Researchers discover that the GPR3 receptor acts as an immediate-early gene to jumpstart neuron and synapse development.

A new discovery from an international collaborative research team has solved the mystery of how cells turn on their recycling process and create "garbage bags" to remove proteins. The process of how ...

Omaveloxolone (approved for Friedreich's ataxia) may help protect cells from stress and correct underlying dysfunction in SMA ...

Full-body defense does not always look the way textbooks say it should. In planarian flatworms, a newly identified cell type ...

Introduction Sjögren’s disease (SjD) is a systemic, rheumatic autoimmune disorder evidenced by broad organ-specific ...

Researchers from the Keck School of Medicine of USC have developed a new type of chimeric antigen receptor (CAR) T cell that elicits a more controlled immune response to cancer in mice—effectively ...