Nature

Understanding rare genetic variants within the terminal pathway of complement system in preeclampsia

Preeclampsia (PE) is a common pregnancy-specific vascular disorder that affects approximately 3% of pregnancies [1, 2]. It accounts for over 50 000 maternal and 900 000 perinatal deaths annually [3, 4 ...
Nature

Extracellular mitochondrial DNA activates complement and is associated with complement activation in patients with out-of-hospital cardiac arrest

Synthetic analogues of mitochondrial DNA (mtDNA) have been reported as potent complement system activators. This study investigated the impact of endogenous mtDNA on complement activation. mtDNA and ...
Healio

‘Important discovery’ shows how complement cascade drives systemic inflammation

Please provide your email address to receive an email when new articles are posted on . A protein known as granzyme K was recently shown to be a driver of inflammation by activating the complement ...